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Opaleye Management Inc. Insider Trading Activity
Every SEC Form 4 transaction reported by Opaleye Management Inc., sourced directly from SEC EDGAR and updated as new filings are accepted.
By Trabud · Insider-trading data from SEC EDGAR
Latest filing:
Compiled automatically from SEC EDGAR Form 4 filings and refreshed daily. Figures count purchases (code P) and sales (code S) only — not grants, option exercises, or gifts. How this page is built. Not investment advice.
Quick Answer
Is Opaleye Management Inc. buying or selling?
Opaleye Management Inc. reported 175 open-market buys ($70.6M) and 41 sells ($28.7M) across 216 Form 4 filings at 11 companies — a net buying position of $41.9M.
Source: SEC EDGAR Form 4
What stands out
- Opaleye Management Inc. has reported Form 4 transactions at 11 companies; the most active, Tracon Pharmaceuticals, Inc. (TCON), accounts for 35 of 216 filings (16%).
- The most recent Form 4 was accepted on Oct 17, 2026 (2 days ago).
- In the last 12 months: 56 open-market purchases ($20.6M) and 10 sales ($11.6M).
- The largest open-market sale in the last 12 months was $4.8M of Eton Pharmaceuticals, Inc. (ETON) on Jul 7, 2026. SEC ↗
Key Statistics (as of Oct 17, 2026)
Total Form 4 filings
216
SEC EDGAR
Companies
11
Buys (175)
$70.6M
Sells (41)
$28.7M
Insider sentiment
Net buyingNet insider flow of $41.9M in net buying, filed between Jan 2, 2020 – Oct 17, 2026.
Companies Opaleye Management Inc. files for
| # | Company | Form 4 filings |
|---|---|---|
| 1 | TCONTracon Pharmaceuticals, Inc. | 35 |
| 2 | HROWHARROW, INC. | 32 |
| 3 | CDXSCODEXIS, INC. | 26 |
| 4 | SLGLSol-Gel Technologies Ltd. | 24 |
| 5 | TARAProtara Therapeutics, Inc. | 24 |
| 6 | ACOGAlpha Cognition Inc. | 23 |
| 7 | TELATELA Bio, Inc. | 18 |
| 8 | ETONEton Pharmaceuticals, Inc. | 17 |
| 9 | GRCEGrace Therapeutics, Inc. | 8 |
| 10 | SNWVSANUWAVE Health, Inc. | 6 |
Recent Opaleye Management Inc. transactions
| Date | Ticker | Role | Type | Shares | Value | Filing |
|---|---|---|---|---|---|---|
| Oct 17, 2026 | GRCE | 10% Owner | Purchase | 71.1K | $136.2K | SEC ↗ |
| Oct 13, 2026 | GRCE | 10% Owner | Purchase | 14.6K | $29.7K | SEC ↗ |
| Oct 5, 2026 | GRCE | 10% Owner | Purchase | 60.5K | $123.8K | SEC ↗ |
| Oct 2, 2026 | ACOG | 10% Owner | Purchase | 19.1K | $165.6K | SEC ↗ |
| Oct 1, 2026 | GRCE | 10% Owner | Purchase | 7.8K | $16.4K | SEC ↗ |
| Oct 1, 2026 | GRCE | 10% Owner | Purchase | 15.1K | $31.7K | SEC ↗ |
| Sep 28, 2026 | ACOG | 10% Owner | Purchase | 31.8K | $270.8K | SEC ↗ |
| Sep 23, 2026 | GRCE | 10% Owner | Purchase | 15.1K | $31.7K | SEC ↗ |
| Sep 16, 2026 | ACOG | 10% Owner | Purchase | 123.9K | $1.1M | SEC ↗ |
| Sep 14, 2026 | SLGL | 10% Owner | Purchase | 3.1K | $207.4K | SEC ↗ |
| Sep 10, 2026 | GRCE | 10% Owner | Purchase | 15.2K | $31.9K | SEC ↗ |
| Sep 9, 2026 | SLGL | 10% Owner | Purchase | 10.0K | $687.2K | SEC ↗ |
| Sep 3, 2026 | SLGL | 10% Owner | Purchase | 1.7K | $116.5K | SEC ↗ |
| Aug 31, 2026 | SLGL | 10% Owner | Purchase | 40.3K | $2.8M | SEC ↗ |
| Aug 19, 2026 | GRCE | 10% Owner | Purchase | 11.6K | $24.2K | SEC ↗ |
| Aug 14, 2026 | SLGL | 10% Owner | Purchase | 951 | $68.0K | SEC ↗ |
| Aug 4, 2026 | ACOG | 10% Owner | Purchase | 52.9K | $423.0K | SEC ↗ |
| Jul 28, 2026 | ACOG | 10% Owner | Purchase | 130 | $1.0K | SEC ↗ |
| Jul 24, 2026 | ACOG | 10% Owner | Purchase | 200.1K | $1.6M | SEC ↗ |
| Jul 17, 2026 | ETON | 10% Owner | Sale | 28.3K | $1.1M | SEC ↗ |
| Jul 16, 2026 | ETON | 10% Owner | Sale | 28.3K | $1.1M | SEC ↗ |
| Jul 15, 2026 | SLGL | 10% Owner | Purchase | 1.7K | $124.8K | SEC ↗ |
| Jul 7, 2026 | ETON | 10% Owner | Sale | 126.7K | $4.8M | SEC ↗ |
| Jul 2, 2026 | SLGL | 10% Owner | Purchase | 1.7K | $123.2K | SEC ↗ |
| Jun 29, 2026 | ACOG | 10% Owner | Purchase | 152.5K | $976.5K | SEC ↗ |
Showing the 25 most recent filings of 216. Screen every filing.
Opaleye Management Inc. insider trading FAQ
Is Opaleye Management Inc. buying or selling?
Across 216 SEC Form 4 filings, Opaleye Management Inc. reported 175 open-market purchases totaling $70.6M and 41 sales totaling $28.7M — a net buying position of $41.9M.
Which companies does Opaleye Management Inc. file Form 4s for?
Opaleye Management Inc. has reported insider transactions at 11 companies, most often Tracon Pharmaceuticals, Inc. (TCON), HARROW, INC. (HROW), CODEXIS, INC. (CDXS), Sol-Gel Technologies Ltd. (SLGL), Protara Therapeutics, Inc. (TARA).
How far back does Opaleye Management Inc.'s filing history go?
Trabud holds Opaleye Management Inc.'s SEC Form 4 filings from Jan 2, 2020 – Oct 17, 2026, sourced directly from SEC EDGAR.
Where does Trabud get Opaleye Management Inc.'s insider trading data?
Directly from SEC EDGAR Form 4 filings. Every transaction on this page is a real filing accepted by the SEC, updated as new filings arrive.
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